SOILS4MED has the following objectives:1) Engage with stakeholders (SH) in line with the EU Soil Mission’s Living Lab approach, develop capacities, and raise SH awareness on the benefits deriving from increased investment in soil data and information (SDI); 2) develop policy relevant integrated indicator sets and a LUCAS-inspired soil monitoring protocol, adapted to the environmental specificities and SH needs of the Mediterranean region (MR), for region-wide harmonized assessment of soil ecosystem health; 3) validate the monitoring protocol in study areas representing major agro-ecological regions and soil types across the MR, generating the first ever large harmonized soil health open access dataset for the MR; 4) Demonstrate the capacity of the SDI produced by the protocol, integrated by legacy soil data, to feed multiple state of art tools to support sustainable soil and water management (SSWM), land degradation neutrality, ecosystem service assessment, precision farming, and to support the generation of regional soil condition maps including carbon stock maps; and 5) design and implement a tailored, easily accessible, standardized soil information system (SIS) software tool for the effective management and use of SDI for the assessment of soil health in the MR.